FOXP3 anticorps (Biotin)

N° du produit ABIN2853612

L’anticorps Rat Monoclonal anti-FOXP3 a été validé pour FACS et IHC (fro). Il convient pour détecter FOXP3 dans des échantillons de Souris.

Aperçu rapide pour FOXP3 anticorps (Biotin) (ABIN2853612)

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXP3 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: MF-14

Détail du produit anti-FOXP3 anticorps (Biotin)

Specificité: This antibody reacts with mouse Foxp3.

Purification: Protein G agarose

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: PBS containing 1 % BSA and 0.09 % NaN3

Stock: 4 °C

Stockage commentaire: Store at 2-8 °C.

Détails sur FOXP3

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Autre désignation: FOXP3

Sujet: Forkhead-winged helix P3 (Foxp3), also known as Scurfin or JM2, is a 50-55 kDa transcription factor, originally identified as the gene defective in Scurfy mice. Scurfy mice and humans with similar mutations spontaneously develop autoimmune diseases (IPEX). Resent reports revealed that Foxp3 is expressed in CD4 + CD25 + regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4 + Foxp3 - T cells induced a Treg-like phenotype in these cells. Importantly, these reports indicate that Foxp3 is a specific marker for Treg cells. Taken together, Foxp3 is believed to be a crucial regulator of the development and function of Treg cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

ID gène: 20371

NCBI Accession: NP_001186276

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation